Tablet Velocity Measurement and Prediction in the Pharmaceutical Film Coating Process

Numerical Simulation of Film Formation in Tablet Coating

The application of a coating layer on a tablet is a commonly used technique to selectively control tablet characteristics. Among the most important functions of the coating is the regulation of the release of active ingredient. In the course of a typical coating process, the tablet passes a spray zone multiple times. Each time, a partial coating layer is applied. For each tablet, this is repeat...

Improvement of the pharmaceutical coating process by rotational rheological characterization

Each film coating formulation and film forming polymer has an individual limiting maximum viscosity value for processability which depends on the type of nozzle and coater used, as well as on the batch size. In order to optimize efficiency and quality, knowledge of the formulation dependant viscosity curves is absolutely necessary. Fig. 1: Thermo Scientific HAAKE RotoVisco 1 rotational rheomete...

Flexible Multipurpose Continuous Processing of Pharmaceutical Tablet Manufacturing Process

Atomization of Liquids Relevant to Pharmaceutical Tablet Coating. Experiments and Droplet Size Modelling

This paper describes a collaborative theoretical and experimental research effort to investigate the performance of co-axial atomizers utilized in pharmaceutical tablet coating when atomizing common tablet coating solutions under typical processing conditions. In pharmaceutically relevant applications, the liquids being atomized are typically complex, non-Newtonian fluids which may contain poly...

Influence of Film Coating Process Parameters on the Gloss of Tablets Coated with Pigmented Aqueous Film Coating Formulations

Opadry® II 1 Influence of Film Coating Process Parameters on the Gloss of Tablets Coated with Pigmented Aqueous Film Coating Formulations PURPOSE A common practice for enhancing the gloss of coated tablets is the application of a clear top-coat after applying a pigmented coating layer. In a recent study, substantial increases in tablet gloss were achieved using this multiple step approach.1 It ...